Meropenem-induced Haematological Abnormalities in the Elderly: A Series of Three Cases
Sharadashri Rao, Kuladeepa Ananda Vaidya
1. Associate Professor, Department of Pharmacology, Srinivas Institute of Medical Sciences and Research Centre, Mangaluru, Karnataka, India.
2. Professor, Department of Pathology, Srinivas Institute of Medical Sciences and Research Centre, Mangaluru, Karnataka, India.
Correspondence Address :
Sharadashri Rao,
Associate Professor, Department of Pharmacology, Srinivas Institute of Medical Sciences and Research Centre, Mangaluru-574146, Karnataka, India.
E-mail: sharadashrikvaidya@gmail.com
Abstract
Meropenem is a broad-spectrum antibacterial agent given empirically for diseases caused by single or multiple susceptible bacteria in both adults and children with a wide range of serious infections. Several studies have reported an association between meropenem and haematological abnormalities such as leukopenia, thrombocytopenia, neutropenia, and haemolytic anaemia. In this case series, the authors present three cases - one with meropenem-induced leukopenia and the other two with meropenem-induced thrombocytopenia. In the first case, leukopenia was observed on the third day of administration. The leukocyte count dropped to 3,500 cells/mcL but recovered upon discharge. In the other two cases, the platelet count dropped below 1.3 lac/cu.mm on the fourth day of administration but started to recover once the antibiotic was discontinued. This underscores the importance of being vigilant and conducting regular laboratory blood counts when administering antibiotics like meropenem to prevent life-threatening complications.
Keywords
Adverse drug reaction, Leukopenia, Thrombocytopenia
DOI and Others
DOI: 10.7860/JCDR/2024/69325.19223
Date of Submission: Dec 28, 2023
Date of Peer Review: Jan 13, 2024
Date of Acceptance: Feb 21, 2024
Date of Publishing: Apr 01, 2024
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Dec 29, 2023
• Manual Googling: Jan 19, 2024
• iThenticate Software: Feb 19, 2024 (12%)
ETYMOLOGY: Author Origin
EMENDATIONS: 6